Well, a recent Forbes piece forced me to re-think a bit about my own weekend track record. Bruce Booth wields a mighty megaphone, arguing that equity, financial risk, and personal time investment in biotech startups drive innovation in ways that pure translational research cannot. He drops in a real gem near the middle:
"A great chemist in a drug discovery startup can personally change the trajectory of the equity of the startup with a new lead series. Working over the weekend actually might change the outcome of a startup."
Marshmallow Fluff Pac-Man
I do have a possible explanation. Weekend work, though it takes away from social and family time, presents an opportunity for your brain to think in different ways. To escape the work week drudgery, break the mold, maybe read that random paper or set up that "this will never work, but hey..." experiment in the back of your hood. Maybe that's where true innovation happens.