|Source: Org. Lett. | Walsh group|
A certain passage caught my eye, midway down the second page (emphasis mine):
"...four common solvents [toluene, cyclopentyl methyl ether (CPME), dioxane, and dimethoxyethane (DME)] were screened..."All 'common' solvents, even CPME? I don't recall seeing that solvent in Trevor Laird's OPRD piece. Or on several solvent boiling point charts. In fact, I don't think I've ever used it...and I'm doing cross-couplings all day!
A quick literature dig on CPME turned up this OPRD, perhaps its grand introduction to the process scene. Looks like it exhibits several advantages over diethyl ether (higher boiling, lower peroxide formation), and improved safety metrics over dioxane or THF.
Readers: Am I just late to the game? Are process folks everywhere charging liters of CPME into reactors 24/7? Please clue me in.