Showing posts with label organic chemistry. Show all posts
Showing posts with label organic chemistry. Show all posts

Wednesday, September 10, 2014

Bill Gates' Chem Secret

*Update - I see CJ beat me to it!

Buried deep within a recent NY Times Magazine article, a humbling reminder that not all knowledge comes easily to billionaire tech scions:
source: Microsoft
"Without prompting, [Bill Gates] recounted getting a bad grade in an eighth-grade geography course (“They paired me up with a moron, and I realized these people thought I was stupid, and it really pissed me off!”) and the only C-plus he ever received, in organic chemistry, at Harvard (“I’m pretty sure. I’d have to double-check my transcript. I think I never ever got a B ever at Harvard. I got a C-plus, and I got A’s!”)."
I can't help but draw a connecting line to one of my fictional heroes, as ChemBark noted.

O-Chem is hard. I guess I'm lucky it made sense to me.

Wednesday, November 7, 2012

#Chemjobs: Fellowship Freefall

Back in graduate school (*cough* ages ago), I distinctly recall looking forward to the annual announcement of the Division of Organic Chemistry (DOC) Graduate Fellowships. The competitive awards, which require advisor recommendations, essays, and a pretty slick research record, granted the lucky few a full year's stipend along with travel funds to attend the National Organic Symposium.

When I clicked for the 2012-2013 crew, I felt something was missing...where's all the fellowships? I counted only eight grantees. Not to condemn them; their research certainly merits the award, but didn't the DOC used to give out a whole pile more?

In a word: yes. Here's the historical data for the grantees, taken from this website


Talking points:

1. Lines, lines: It's not an accident that the trend mirrors the overall economy generally, and employment in Big Pharma specifically. Note the huge uptick in awards between 1997 and 2001, when the average was ~18 per year. Boom times. It's since settled down to just about 8 annually, around the average of the recession-era '80s.

2. Visits: Those last seven years (2006-2012) match the corresponding decline in corporate recruiting (see MIT, Harvard graphs via Chemjobber).

3. Strange birds: Since graduate school enrollment has dramatically increased, at the same time as fellowships have decreased, these awards become even more prestigious, if only by dint of rarity.

4. Peak Perfection: Let's look at the top year: 1997, when 19 fellows were named. Who sponsored the awards? Take a trip down memory lane...

Wyeth-Ayerst
Abbott
Pfizer
DuPont Merck
Hoescht-Marion Roussel
Org Syn (x 3)
Organic Reactions
Boehringer Ingelheim
Zeneca
Bristol-Myers Squibb
Procter and Gamble
Pharmacia-Upjohn
Eli Lilly
Smithkline Beecham
Merck Research
Rohm and Haas
Schering-Plough

Wow, how many of those guys even exist anymore? Contrast this list with the 2012 crop:

Merck / Division of Organic Chemistry
Org Reactions / Org Syn
Genentech
Boehringer Ingelheim
Org Syn (x 2)
Amgen
Troyansky (family endowment)

Pretty slim pickins.

5. Winners? Losers? Some auspicious names have been missing from the DOC Fellows' list in recent years: Harvard, MIT, Scripps? Actually, the trend improves for state schools, with 5/8 in 2012 going to the public universities. Compare this to 1995 ("boom times"), when the list included Harvard (x 2), Stanford (x 2), Johns Hopkins, Northwestern, MIT, Yale, USC, Chicago, and the publics represented by Berkeley (x 2), Wisconsin (x 2) and Utah.

Note: Thanks to Chemjobber for the inspiration.
Update (11/8/12) - Fixed USC, not a public uni! Thanks, Anon commenter...also Chicago..

Saturday, October 13, 2012

The Chemical 'Real Book'

Buying a Real Book is complicated.

For the uninitiated, the Real Book provides jazz charts, including chord progressions, lyrics, and harmonies for gigging musicians playing in bars and clubs. It's something of a badge of honor, like a construction worker's tool belt or the chemist's model kit and beat up copy of March's 3rd Edition.

It's also technically illegal.

Hand-drawn charts from The Real Book
See, the Real Book cobbles together scraps of published music, overheard solos, and lyrics cribbed from cocktail napkins, and publishes them on fuzzy photocopied pages. No copyright information, official publisher, or complex index. Just 400 pages of non-ASCAP-approved* scribbles. But, funny thing: everyone has one, because they're so darn useful. If an audience member suddenly shouts out "play God Bless the Child" or "Mood Indigo," you can just flip to the right page (136 and 242, if you're curious), and go.

I'm amused how often organic chemistry and jazz dovetail together. Something about the overlap between formalized education - scales and chords for the musician, periodic trends and name reactions for the chemist - and free, artistic improvisation jives with both fields. Both have subdivisions, leading lights, and roguish subcultures.

So, I have to ask: Where's the O-Chem Real Book?

You could say that PiHKAL, the "how-to" book scribed by the Shulgins, might be our version. But even that tome has a publisher, typeface, and a copyright! I'm curious about even more clandestine collections of notes, like a longer version of those clipped-together, ragged notebook pages of hand-drawn structures everyone prepares before final exams. Does anyone still have those, and do you use them to inform your lab work? Do any chemistry professors prepare photocopied books that you collect from University Press just before the semester starts?

Real Book Cover
Even if these books exist, acquiring them might be less fun than the rite of passage required to buy my Real Book.* Ten years ago, I walked into a back-alley, nondescript music store. I asked the clerk fairly routine questions, then glanced towards the bound anthologies on the wall. He told me he didn't know, and motioned towards the end of the counter. Money, that I didn't know if I'd see again, went onto the counter. The clerk nodded, and told me to come back in 20 minutes. A paper bag awaited me near the back of the store.

*Coda: Although I own a copy of the book, I don't condone theft, especially of intellectual property. Songs count. When I need actual sheet music for a group or performance, I always purchase it directly from the composer or ASCAP-approved music shop.