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| Source: Decon Labs |
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| Never thought I'd be taking a soapy NMR... |
Best part? It's not a contaminant in my material. On to the next project!
Thursday, January 2, 2014
A Soapy Situation
Life has funny ways of surprising you. While analyzing my latest batch of a functionalized sugar, I noticed that the NMR sample foamed upon sonication. Fearing surfactant (read: soap) contamination, I found myself back at the instrument facility with a D2O sample of...Contrex, the orange-labeled glassware rinse I've used ever since I started working at the bench.
Unsurprisingly, Decon Labs doesn't list its trade-secret formulation on the MSDS or their website. However, this doesn't seem like something I'm going to investigate a la What's In Lemi-Shine? Seems to be to be a typical mono-aromatic tetraalkylammonium salt, probably containing some KOH, phosphate, or bicarb for good measure.
Best part? It's not a contaminant in my material. On to the next project!
Best part? It's not a contaminant in my material. On to the next project!
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if you are putting something fairly big and greasy on your (otherwise deprotected) sugar, it is going to behave like non-ionogenic detergent.
ReplyDeleteSure....especially if it's a big ball o'grease : )
ReplyDeleteIt's not a bug, it's a feature. It's not a contaminant, it's the compound.
ReplyDeleteThere are quite a few funcitionalized sugars that are surfactants. Decyl glucoside comes to mind.
ReplyDelete