|The Whisky-a-Go-Go, 1965, Los Angeles|
Credit: WFMU Ichiban Radio
Yup. Biologists love a good play on words. Among the well-known Drosophila (fruit fly) genes are lush, sonic hedgehog, and methuselah*. In our bodies, certain drugs interact with the hERG receptor, one of several human homologues (close matches) to fly genes. But I hadn't realized that this PK point of conversation was named for a night club in L.A.
Ever heard of a "go-go" dancer?
Urban legend holds that famed club Whisky a Go-Go, a 1960s rock music hotbed, first institutionalized the profession when it opened on the Los Angeles Sunset Strip. To capitalize on a popular trend from New York and Paris, the owners set girls to "go-go" dancing in large cages suspended from the ceiling.
|Not a Drosophila geneticist.|
As recounted in a 1991 Science News feature, neurogeneticist William Kaplan first noted the ether-à-go-go (eag) mutation in the 1960s. If these flies were knocked out with ether, their legs would twitch and shake, much like the famed dancers. When two researchers from the University of Wisconsin discovered similar mammalian genes, they took a page from the same book, naming them "erg," or "ether-à-go-go related genes."
ECG of a single heartbeat
Source: Wikipedia Commons | Agateller
Warmke and Ganetsky, the two Wisconsin geneticists, found that the hERG gene encoded specific voltage-gated potassium channels in cell membranes (i.e., they open and close to allow potassium ions to flow out of the cell). In heart cells, these channels control the back-end of the heartbeat, the so-called "QT interval" (see graphic). When drugs block these channels, cardiac membrane repolarization (electrical charge balancing) takes longer, and a fatal arrhythmia may set in.
*Decoder ring: lush mediates alcohol response, sonic hedgehog (shh) controls organ and limb differentiation, and methuselah creates long-lived flies