Football Pain? Solve it with Solvent

A friend pointed me towards ESPN's recent interview with former Dallas Cowboys defensive lineman Tony Casillas. When asked about the recent hullabaloo regarding deer antler spray, Casillas reportedly answered: "That's nothing. We used to use this stuff called DMSO..."

DMSO? Dimethyl sulfoxide? Like, the polar aprotic solvent we all know and love from the Swern oxidation?

The very same.*

I hadn't realized that the compound had such a long history in medicine. Suppose I should have remembered hearing Breslow once talk about DMSO as his inspiration for the development of SAHA (vorinostat). Still, after the heated warnings I've always received from tox folks while handling DMSO stock solutions (Double gloves! Wipe up spills ASAP!), I'm hesitant to try it myself.

*A note of caution: I'm not endorsing rubbing DMSO on your balky knee or tennis elbow. You should always ask a medical professional before trying something like that. Please don't say "I read this on a blog..."

ESPN Anchormen - Secret Chemists?

Just in time for Super Bowl 46 (XLVI, for those playing in ancient Rome), The New York Times recently published a humorous collage of ESPN sportscasters' cliches over the past six months of NFL coverage. One tract specifically caught my eye:

"Ray Rice, dynamite running back — he's literally the catalyst for this Ravens offense."

Ray Rice: The Grubbs II of the Ravens' offense

Wow, two chemical terms in the same sentence! I understand, then, that Ray Rice, in addition to being a nitroglycerin-soaked fiber cylinder with a blasting cap, can also reduce kinetic barriers (tackles?) to fundamental reaction steps (gaining touchdowns, no doubt). 

I can see the similarity, if I look hard enough. After all, both football and chemistry research share collisions, (grid)iron, receivers, and a love of all things statistic. 

Just don't compare high "turnover numbers" (TON)...the NFL doesn't look as kindly on those as scientists do!

Enjoy the big game, everyone. Go Pats!

Friday Book Club

Books, chairs, and lamps = happiness

I live in a sleepy town of about 28,000 people. Quiet, picture-postcard-like scenery. A few coffee shops and pizza joints. Schoolchildren, soccer moms, and tall pine trees. The type of town where a visit to the local library might normally turn up mysteries, nonfiction, and children's books, but not a lot of science content.


So, imagine my surprise at finding a veritable treasure trove in our "New Books" section last week. As I strolled by, I couldn't help scooping up everything I laid my eyes on.


Carl Zimmer's A Planet of Viruses was there. As was Much Ado About (Practically) Nothing, a book about the history of noble gases, by David Fisher. A few rows down, I encountered How I Killed Pluto (And Why it Had it Coming) by Mike Brown, and one row to my right was Rob Dunn's The Wild Life of Our Bodies: Predators, Parasites, and Partners that Shape Who We Are Today. Toss in the obligatory Feynman biographies, and a book or two about popular physics, and I was in science reading heaven.


Looks like a long weekend of coffee and reading (and maybe a game) for me.  Enjoy, everyone!

Team Chemistry

A friend and I recently traded barbs back and forth comparing NFL Pro Days and chemistry lab culture. 


For the unfamiliar, during the recruitment process, colleges host scouts from various NFL teams while exhibiting their athletes' skills in various strength, speed, and coordination drills. 


Without further ado...


"He wrapped up that running back like Parafilm!"


"I calculate molarity more accurately than Drew Brees throws the deep ball."


"For good protection in the pocket, make sure you're using reagent-compatible lab gloves."


"My signing bonus? A monogrammed lab coat and an Aldrich mouse pad."


"Neither my advisor or I knew the answer, so we punted."


"That safety covered him better than a full-face respirator!"


(I could go on, but I'll let you readers have a crack at it!)

Musings: Who are Chemists, Anyway?

When I’m performing a repetitive lab task (columns, iterative dilutions, etc.), my mind tends to drift. Yesterday, I began thinking about who I actually work with, where they come from, and why they’re in chemistry. Ever heard Jeff Foxworthy perform “You Might be a Redneck if…”? What if someone were to compile a similar list about synthetic chemists?

Thus, a few observations, from the subset of, say, 300 chemists I’ve worked with over the last ten years:

"It's OK, Dom, I'm leaving baseball for grad school"
Credit: AP

They tend to be older siblings: Perhaps there exists out there somewhere a biotech run entirely by younger sibs, but I haven’t found it yet! At my current job, all senior managers are the oldest siblings in their families, and I’m fairly certain most of the bench chemists have younger brothers and sisters. Maybe the old nature / nurture debate surfaces here, where parents encourage older children to pursue medical and scientific careers.

Folks come from all over: I hail from a town that the 2000 Census dubbed >95% Caucasian. Many of my friends went off to school, and then moved immediately back to town. After college, I moved 700 miles away, possibly to escape this exact fate! This "lifestyle inertia" has never occurred at any of the six labs I’ve worked in: the scientific population integrates well (math joke here?). My coworkers have hailed from all over the US, plus every continent except Greenland. It’s fun to watch Russian postdocs tell jokes to Indian coworkers, while French, Chinese, and Iranian labmates listen in and laugh.

Tech-savvy:  The first Blackberry I ever saw was wielded by a chemist. Ditto iPads, USB sticks, and noise-cancelling headphones. In grad school or college, you’ve probably used MacOS, UNIX / Linux, and most of the Microsoft Office suite, and you may have created .pdfs, manipulated graphics files, or solved crystal structures. It comes with the territory.



Merit badges = Future PhD?
Credit: watc.edu



Be Prepared? Four of my former coworkers were Eagle Scouts, and several more have EMT and First Responder training. Safety first.

Hobbies? Try second careers: Bench chemists live two lives: they’re passionate about their chemistry, but everyone has a hobby that they could fall back on (maybe a necessary practice in a bum economy). I’ve met semi-professional musicians, day traders, lay pastors, auto mechanics, authors, aerobics instructors, economists, coaches, show promoters, bodybuilders, shop owners, and even professional dancers.

Credit: rushpassport.com

World Travelers: Maybe this makes sense given their international background, but chemists travel all over. Many save up their whole vacation allotment for 2-3 years, and then go to China, France, Australia, or Argentina. Back when large chemical concerns had travel budgets (I know, a novel conceit), chemists could rely on at least one expedition per year, usually to attend a big conference in a far-flung locale.

Not Fashion Plates: You won’t see many chemists dressing like the men and women striding down docks in J.Crew, or taking nighttime strolls like they do in Ralph Lauren catalogs. Perhaps it’s thrift, or comfort, or maybe chemists just realize that their clothes have limited lifetimes in synthetic labs.

Office Pool?  Of course!  Chemists tend to jump at opportunities to participate in NCAA tourneys, fantasy football, or poker nights. Maybe it’s the competition? The odds? The logic? Who knows! I’ve worked in labs where two competing tournaments have been run simultaneously…and both found plenty of participants.

Wanna join our league?
Credit: tradebit.com

One-Upsmanship: Many of the conversations I’ve had with older chemists invariably come down to competitions over how hard the job once was. Usually, they begin with “Oh yeah? Well, when I was your age, we had to recrystallize everything to purity, we didn’t have working fume hoods, and we actually used the (insert here name of old, dusty apparatus in the corner no one ever uses).” Maybe this speaks to how much synthetic chemists enjoy competition (see above).

War Stories and Battle Scars: No, I’m not talking about actual military service, although I’ve worked with a few chemists who have bravely fought alongside our troops. I refer to tales career chemists always tell at bars, stories where pump traps explode, flames shoot up from flasks, and injury was narrowly avoided. If you work in a synthetic lab long enough, you’ll have a few close calls, and you might even have something to show for it: a bald spot here, a burn there, even some stitches now and again.