Showing posts with label Whitesides. Show all posts
Showing posts with label Whitesides. Show all posts

Tuesday, February 17, 2015

Whitesides' Chemical Future

As part of the "Future of Chemistry" essays sponsored by BASF, professor George Whitesides opines in Angewandte Chemie Int'l Edition that chemistry must change in order to keep pace with societal demands and changing scientific landscapes. 

Familiar themes pepper his prose: the tension between "curiosity-driven" and "directed" research, between organizational behavior, motives, and rewards, and several pressing calls to action. After setting some ground rules and introducing us to his main actors - academia, industry, and government - George shifts his essay towards some familiar* grand challenges:
"What is called 'chemistry' now may only be a distant cousin to the chemistry of 50 years from now."
Origin of Life. Informatics. Energy generation, storage, and usage. Cognition. Human augmentation. Death. In twenty-two points, he covers the entire human experience from life to death, from single cells to complex global societies, then leaves himself two outs: numbers 23 ("All the rest") and 24 ("Combinations with adjacent fields").
"Chemistry tends to be excessively modest in its ambitions. Excessive ambition might sometimes be a better strategy."
Hold on for a minute...anyone feel a strange sense of déjà vu? For the past three decades, Whitesides has been in the business of not just inventing the future, but actively predicting it as he goes:

2013: Reinventing Chemistry - RSC Roadshow
2013: Memo to Chemists: Move Away from the Molecule
2013: A Glimpse Into the Future of Diagnostics
2012: Whitesides on Discovery and Development
2011: Whitesides & Deutch on What's Wrong with Academia
2011: Chemistry and the Worm
2010: Towards a Science of Simplicity
2007: Revolutions in Science
2004: Assumptions: Taking Chemistry in New Directions
2001: The Once and Future Nanomachine
1999: Complexity in Chemistry
1995: Holy Grails of Chemistry
1990: What Will Chemistry Do in the Next 20 Years?
1988: Materials for Advanced Electronic Devices - Chemistry for the Future
1986: The Role of Chemistry in Materials Science

Certainly, this essay reads like anything other than a traditional chemistry text. We hear about chemical granfalloons** -- who are synthetic organic chemists, anyway? -- catalytic networks, Facebook and Twitter ("avatars of social engineering"), and even the rather Huxleyan concept of population control. Pasteur's quadrant, aka the choice of research that solves social problems while inventing fundamentally new science, represents for Whitesides the idealized goal, though he admits we're presently much more stuck in the "Liebig apprentice model" of traditional research groups.

Especially resonant for me were the areas Whitesides identifies at collaborative interfaces: megacity logistics and cancer prevention involve far more cooperation along "unfamiliar boundaries" than I had perhaps realized: social, environmental, computational, psychological, and (of course) chemical.

Flying cars - Still not a priority for chemists...yet.
Source: Terrafugia

I found Whitesides' friendly, casual conversation with the reader, breaking down traditional scientific narrative for a personal exchange, rather refreshing. You can actually hear him speaking through the page, his calm, familiar cadence and confident, challenging affect. Recall that George himself has opined often on just how to communicate scientifically; looks like he indeed follows his own presciptions.

I recommend a full read-through for those so inclined. I'll close this meta-review with two points. First, a strong piece of advice from Whitesides' 2007 Priestly Medal address:
"Chemists are the natural leaders for much of the research that needs to be done. But physicists can learn molecular detail, and biologists can learn differential equations. If we do not wish to work on these problems, others certainly do. If it is not our revolution, it will be someone else's."
Finally, Whitesides offers a poignant answer to the age-old stuck-on-an-airplane question: What do chemists do? I won't give away the answer here, but suffice to say it's both more direct and more engaging than how I've traditionally answered. Go have a look.

----
*So familiar, in fact, that he references two of his own previous predictive essays. See also, from Philip Ball, here
**I'll follow professor Whitesides' daring example of directly citing Wikipedia for this Vonnegut quote.

Friday, May 31, 2013

Friday Fun - Superlative Publishers

Who's got the highest total # of published papers among living synthetic chemists?

Criteria: The person runs a group that makes things - sorry, no theorists this round - and works principally in some sub-field of synthetic chemistry (organic, organometallic, inorganic, photochem, med-chem, polymers, etc). 

I opened the discussion up on Twitter this morning, and used SciFinder, backed up with [cough] group websites that often need updating [cough]. 

Here's the list, as of 10:00 CST...

(All counts rounded to nearest 100 for convenience. SciFinder is an imperfect metric, since it includes abstracts and some duplicate entries. Please refer to caveats, below, for more detail.)

Alan Katritzky: 2,200 website; 2600 SciFinder

Source: exchangewire.com
Robert S. Langer: 2000 SciFinder
George Whitesides: 1,200 website; 1900 SciFinder
Leo Paquette: 1500 SciFinder
*E. J. Corey: 1,000 website; 1500 SciFinder
J. Fraser Stoddart: 1,000 website; 1400 SciFinder
Tobin J. Marks: 1,000 website, 1600 SciFinder
Paul v. Rague Schleyer: 1,300 website; 1600 SciFinder
Jean Frechet: 800 website; 1300 SciFinder
Irina Beletskaya: 1300 SciFinder
Barry Trost: 900 website; 1200 SciFinder
K.C. Nicolaou: 700 website; 1200 SciFinder
D. Reinhoudt: 1200 SciFinder
J. S. Yadav: 1,000 website; 1200 SciFinder
Ben Feringa: 1100 SciFinder
J-M. Lehn: 1100 SciFinder
E.W. "Bert" Meijer: 1000 SciFinder
Robert "Bob" Grubbs: 1000 SciFinder
Virgil Percec: 1000 SciFinder
Samuel "Sam" Danishefsky: 700 website; 1000 SciFinder
Ryoji Noyori: 800 SciFinder
Steven Ley: 900 SciFinder
Amos B. Smith: 900 SciFinder
James Tour: 500 website; 900 SciFinder
Stuart Scheiber: 500 website; 800 SciFinder
Karen Wooley: 700 SciFinder
Peter Langer: 700 SciFinder
Carolyn Bertozzi: 700 SciFinder
Jean'ne M. Shreeve: 500 website; 700 SciFinder
JoAnn Stubbe: 600 SciFinder
John Hartwig: 300 website; 600 SciFinder
K. Barry Sharpless: 600 SciFinder
Jacqueline Barton: 300 website; 600 SciFinder
Gautam Desiraju: 500 SciFinder
J.K.M. Sanders: 500 SciFinder
Ted Taylor: 500 SciFinder
Laura Kiessling: 400 SciFinder
M. Joullie: 400 SciFinder
Cynthia Burrows: 300 SciFinder
Melanie Sanford: 200 SciFinder

(Update: 1PM - Added Tobin Marks, Virgil Percec. 6PM - Added top-author women chemists. 7PM - Added Frechet, Desiraju, Sanders. 12AM 6/1 - Added Shreeve, Beletskaya)

Some caveats: I know it's folly to attempt correlating total publication count : scientific 'genius.'
If you only publish one paper, but you cure a major disease or invent a top-selling polymer additive, you're doing just fine! 

Also, I note that not everyone agrees that folks on this list belong in the "synthetic chemist" bucket - see ScienceGeist's (noted) exceptions here. (Update: P-O. Norrby noted another exception...)

Importantly, graduate students shouldn't feel down and out about this list. You can have a perfectly fine career with just a handful of papers; these superstars are the exception rather than the rule.

Curious thought: Publications in large synthetic groups certainly seem to follow a power law** - it takes ~15 years to get those first 100 papers, then about 8 for 100 more, and then the pace picks up dramatically. Presumably, this represents added hands and minds, along with building respect and excitement for one's work. I don't know how many other factors (prizes, location, grants, "buzz") are involved, but they probably belong to another post.

Readers, what say you? Have another person I've missed on the list?

*Who knew E.J. pwned ejcorey.com? (show of hands?) I think I smell a fantastic cyber-squatting campaign ...danishefsky.com, anyone?

**An example we discussed on Twitter: Phil Baran. It took him 15 yrs (1997-2011) to get 100 pubs. Next 25 or so have only taken 2 yrs. If power law holds, he'll have >400 pubs by age 50.

Monday, March 25, 2013

Hawker's Talk Secrets

"My Chemical Romance Calls it Quits"
"My Chemical Romance, In Memoriam"
"My Chemical Romance Break Up"

Never fear, dear readers: My 'chemical romance' continues unabated...[rimshot]

At the risk of sounding like a lounge act, I realize that clear communication supports good relationships. So, apparently, does Craig Hawker, an accomplished polymer scientist at UCSB. I've seen him present a few times; the man gives one hell of a talk!

This month, he shares his secrets with you courtesy of a (free!) Angewandte Chemie editorial. Building off the success of Whitesides' essay "Writing a Paper", Hawker points out a crucial difference:
"While a publication can be read again and again, a presentation is over immediately. Therefore, the rules for writing a publication differ from those for preparing a presentation."
Amen! We've all attended deadly discourse disasters: The 9AM conference sleeper. The 4PM no coffee, no snack, sotto voce speaker with tiny font. The don't-stop-for-questions local section dinner meeting. All tragic wastes of opportunity.

"Chemistry? Chemistry? Chemistry? Chemistry?"
Source: Ferris Bueller's Day Off
So, how can we improve?

Hawker offers several simple pointers, divvied up into two major sections ("The Slides" and "The Talk"). For slides, he argues clarity, simplification, and increasing "signal-to-noise" improves the amount of useful information instilled in the audience.

For speech, Hawker advocates skills that would play well in any concert hall: Practice. Engage with the audience, which includes eye contact and interaction. Project confidence. Modulate your voice, and know when to make use of silence.

Most importantly, argues Hawker, we must solicit active feedback. Like late NYC mayor Ed Koch, ask your audience "How'm I doin'?" An honest answer here may sting, but will help you to improve for next time.

Friday, August 17, 2012

Coloring Soft Robots - "Fun" Supplemental Info?

Have you seen George Whitesides' new soft, color-changing, 3D-printable (huggable?) robots? They're out in Science right now, and Ed Yong's got a rockin' writeup over at his blog.

Source: Science | Discover | Harvard
The silicone based robots, mimics of squid, octopus, and other sea life, are pneumatically controlled - they 'move' when pumped around the lab. Colors are charged via pressurized microfluidic channels, and matched to the critter's surroundings using an algorithm. A few online videos (Harvard, and Science SI) show the robot 'dancing,' trying out its camouflage, and even glowing in the dark.

Reading through the supporting information, I had to chuckle at some of the phrasing that truly differentiates a 'Whitesides paper' from a normal chemist's jaunt. Here's some choice phrases:

"Ecoflex two-part platinum cure silicone rubber kits...purchased from Smooth-On, Inc."

"...we made aqueous solutions colored in the visible spectrum...by mixing and adjusting the relative proportions of gouache watercolor paints..."

"This chemistry is standard for commercially available glow sticks"

"Fluorescent solutions were created by dispensing approximately 2 mL of DayGlo paint...and diluting with 25 mL acetone"

Makes discussions of where you purchased your LAH and allyl bromide seem rather pedestrian, eh?