Showing posts with label Atari. Show all posts
Showing posts with label Atari. Show all posts

Thursday, June 20, 2013

Perks

There's a pithy NY Times round-up of the free food and services NYC tech start-ups lavish on their employees. (SPOILER - they sound awesome):
"Within my first week of working at a start-up, I acquired a gut. The reason was obvious: there was free food everywhere, it was delicious and I was nervous . . .on Monday, warm cookies from the Upper West Side bakery Levain appeared in the kitchen. Buttercream cupcakes followed; apparently it was somebody’s birthday. (It is always somebody’s birthday.) At noon, employees gathered for a catered lunch of barbecue. Two hours later, a Pinkberry station rolled into the office with the full battery of toppings."
The author raises the stakes in each paragraph, moving from free food to beer, coffee, yogurts, fancy juices, then up to concert tickets, in-office manicures, nap times, and - I am not making this up - a room full of puppies.

Wowzers.

Back in my day (in *cough* late '90s small biotech), I distinctly recall watching the first Keurigs pump out decadent self-serve coffee pods, and thinking how lucky we were to have such a great gizmo. Later, I toured a boom-times GSK, noting agog the subsidized food, dry cleaning, in-house gym, etc.

My favorite quote from the article comes courtesy of tech titan Nolan Bushnell, Atari founder (emphasis mine):
"Mr. Bushnell of Atari, a veteran of the start-up world, was asked where he draws the line between 'productive perk' and 'wanton decadence.' His answer: Well, he doesn’t.
'I’ve often felt that it is somehow wrong to have an engineer spend any time at all scrubbing his own toilet,' he said. 'It sounds elitist, but these people are highly important to the economy and to the company. Offering maid service to them as a perk makes total sense.'"
Amazing. Would that all start-ups felt the same way.*

*By my count, I've scrubbed my toilet at least 40 times since starting at my current job. Par for the course. I've heard of start-ups with trash and mop duty, too. 

Friday, February 15, 2013

Friday Fun: All Your Base Are Belong to MOBBs

(With apologies to Ohio)...What's round in the middle and "I" on both ends?

It's a twist!
How does that biaryl bond survive?
Source: OL | ICIQ
If you guessed the newly-reported mu-oxo bridged bisiodones (MOBBs?) reported in Org. Lett., you win. We're all familiar with famous mono-hypervalent iodine reagents: IBX, Togni reagents, iodosobenzene, Dess-Martin, etc., but I'll admit this is the first time I've seen them 'doubled up' like this.

So, aside from a mangled crystal structure - which, if you believe it, almost folds the biaryl in half -  this reagent seems predisposed to rearrange itself in situ, forming a charged pair: [O=I-biaryl-I-NTs2(+)] NTs2(-). Thus, the same molecule decomposes into electrophilic and nucleophilic bis-tosylimides, which can be used to diaminate simple olefins.

Pretty schnazzy.

Now, that's a load of atomic mass to drag around for just two simple C-N bonds. Can we do better? Sure - the researchers demonstrate some early catalytic runs, and along the way swap out the biaryl for a chiral binaphthyl (c'mon, you saw that coming), which induces a proof-of-concept 32% ee.

I'll admit it: when I first saw this abstract pass by, I thought not of reactions but of...invaders. Specifically, Space Invaders, the formative 1978 Atari arcade game where your blocky white tank takes aim at dozens of 8-bit baddies falling from the sky. To me, the fully-formed reagent looks just like the "middle" guy in that picture (see below).


Credit: Atari
Happy synthesizing, happy gaming, and happy Friday!
-SAO