Monday, July 18, 2011

Illegal Drugs Spur Chemists to Create Cures


White powders marketed on grocery shelves as “bath salts” are quickly becoming problematic for politicians and police, as reported in the July 17th New York Times.  These “salts,” derivatives of a compound called methylenedioxypyrovalerone (MDPV) cause many of the same symptoms as methamphetamine intoxication. The wide availability of these new mixtures, compounded by their ease of synthesis and seemingly no lack of supply, has led to an explosion in their abuse (Note: I won’t cover the chemistry behind MDPV, the active ingredient, because my in silico mentor David Kroll’s posts on Terra Sigilata have mostly covered it).
That’s the gist of the article, in which illicit chemical synthesis fuels a new drug craze, and the public perception of chemists is dragged down again by sound bites such as “state bans thwarted by chemists who have to change only one molecule… to make [the salts] legal.” What happened to fair and balanced coverage?
For every illegal manufacturer of psychoactive compounds hoping for addiction to promote sales, there are many more chemists working on analogs of bioactive substances to treat disease.  Compounds that show high potential for abuse tend to interact with three neurotransmitters: serotonin, dopamine, and norepinephrine. In the case of bath salts, the main ingredient is a norepinephrine-dopamine reuptake inhibitor (NDRI), which allows these neurotransmitters to stay longer in the synapse, creating feelings of pleasure and wakefulness. Phenethylamines, such as MDPV, meth, or Ecstasy, the popular club drug, are one major class of compounds which activates these receptors, and are easily tweaked synthetically to prepare drug leads for Parkinson’s disease, schizophrenia, and ADHD.
Prof. David E. Nichols, of Purdue University, has devoted much of his career to understanding the mechanisms by which addictive drugs can interact with brain receptors, and designing novel compounds to take advantage of these traits (See this October 30, 2010 Wall Street Journal piece for Nichols’ comments regarding black market applications of his academic work). Prof. Nichols has synthesized variants of psilocybin, mescaline, and notably for this particular story, MMAI, a “cyclized” version of a typical methamphetamine scaffold.  On the day the NYT article went to press, Prof. Nichols had a J. Med. Chem. ASAP publication (DOI: 10.1021/jm200334c) appear online, in which his group prepared four new methylated analogs of their lead compound dihydrexidine. This analog, developed off the phenethylamine scaffold, has been shown to bind to the D1 dopamine receptor, and both improve blood flow to the brain and to reverse Parkinson's-like symptoms.

Photo Credit: obrag.org
 Two other medicinal chemists are using methamphetamine derivatives as “Trojan horses” to trick the body into immunizing itself against the drugs. Their end goal is a vaccine that could be administered to control meth addiction. Kim Janda, of the Scripps Research Institute, and F. Ivy Carroll of the Research Triangle Institute (just down the block from David Kroll!) have both recently reported their groups’ respective efforts towards methamphetamine vaccines. Each group strategically introduces a hapten, an immunological “stamp” that latches onto a human protein, which the body can use to recruit white blood cells to the foreign substance.

Janda (JACS 2011, 6587) attaches a six-carbon chain ending in a thiol (SH) group to the amino group of (+)-methamphetamine, the more potent enantiomer, and observes high antibody titres in mouse models. Carroll (J Med Chem, 2011, ASAP) also uses a sulfur antigen, but attaches his via an amide linker connected to the aromatic core. After connecting this linker to a suitable immune-responsive protein, Carroll generates a monoclonal antibody with a 6.8 nm KD for (+)-meth.
Update (July 30, 6:50PM) - Changed "bloodstream" to "synapse," since commenter gippgig is (again) correct that the compounds influence synaptic function, not bloodstream chemistry. Thanks!

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  2. Hey! That looks like you got it to work!

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  3. This all gets back to many of the points Raold Hoffman makes so eloquently in "The Same and Not the Same". There are two sides to EVERY chemical. Risk and benefit. There is no miracle drug out there. We need water to survive. But marathon runners can drink too much during a race and seriously damage their bodies. Morphine helps people in excruciating pain, and I don't really need to list the negative consequences of morphine use here.
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  4. The drugs I take to feel normal make others high... Sheesh... Psychiatric diseases stink, glad you all are here to help.

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  5. Shouldn't that be "stay longer in the synapse"? Neurotransmitters generally don't enter the bloodstream to neurotransmit.

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    mephedroneketaminemethylone.blogspot.com

    Our quality is the best you can find around and we sell in small/large quantities with guaranteed discreet delivery in good time Shipping is done Via DHL TNT FedEx.Please Do Include Your Contact Number . All inquiries are welcomed
    We're leading distributor & suppliers of top grade RESEARCH CHEMICALS, STEROIDS AND HUMAN GROWTH HOMONES (HGH) Instant customer support Email marthaperres90@gmail.com. text or call +1 707 335-6162 Whatsapp +1 (438) 300-9284  

    ReplyDelete
  18. Buy high quality  2CI, 2CP,2CE ,2CB,Mephedrone Ketamine Heroine cocaine ,5-Meo-DMT 4-Aco-DMT 4-Ho-MIPT  Mdma and BK mdma crystals and powder methylone Instant customer support OR Email marthaperres90@gmail.com text or call +1 707 335-6162 .whatsapp +1 (438) 300-9284  

    We are located in USA . Buy High Quality Grade(%99.96) Mephedrone (2- methylamino 1-one also known as 4-methylmethcathinone(4-MMC).We one of the leading suppliers in wholesale and retail of research chemicals, steriods, hgh. and other plants food research chemicals such as:
    Mephedrone
    Hexen
    4CMC,
    4CEC,
    BK-EBDP
    2NE1 + APICA,
    3,4-CTMP,
    3MEO-PCP
    3-FPM, 3-MMC
    4-FA,
    4-MEEC,
    5-APB,
    5-EAPB,
    5-Mapb,
    5-MeO-DALT
    5-MeO-DIBF,
    5F-AKB-48,
    5F-PB22,
    6-APB,
    6-APDB,
    A-PVP
    AB-CHMINACA,
    AB-FUBINACA,
    AB-FUBINACA,
    Acetildenafil
    AL-LAD (NEW),
    AM-1220,
    AM-2201,
    AM-2233
    AMT,
    BB-22 + QUCHIC
    Etizolam
    Diclazepam,
    Diphenidine,
    Ephenidine,
    Ethylphenidate
    Etizolam, Evoke,
    Flubromazepam,
    Flubromazolam,
    Funky Buddha
    Funky Silber Buddha,
    Isopropylphenidate,
    M & ms
    MAM-2201
    Marleys Magie, MDAI (NEU)
    MDPV
    Methiopropamine
    Methoxetamine
    Methoxphenidine
    Methylone
    Metizolam
    Mexedrone (NEU)
    Modafiendz
    MPA and 5MD
    Nifoxipam
    NM-2201
    NM-2AI
    Pentedron
    Phenzacaine
    Pyrazolam
    High Sky
    Smokey
    Smokey X
    STS-135
    Synthacaine
    THJ-018
    THJ-2201
    UR-144
    ADRAFINIL (crystal or powder)
    DOC25 (white powder)
    Dibutylone (crystal)
    ADRAFINIL (powder and crystal)

    mephedroneketaminemethylone.blogspot.com

    Our quality is the best you can find around and we sell in small/large quantities with guaranteed discreet delivery in good time Shipping is done Via DHL TNT FedEx.Please Do Include Your Contact Number . All inquiries are welcomed
    We're leading distributor & suppliers of top grade RESEARCH CHEMICALS, STEROIDS AND HUMAN GROWTH HOMONES (HGH) Instant customer support Email marthaperres90@gmail.com. text or call +1 707 335-6162 Whatsapp +1 (438) 300-9284  

    ReplyDelete
  19. Buy high quality  2CI, 2CP,2CE ,2CB,Mephedrone Ketamine Heroine cocaine ,5-Meo-DMT 4-Aco-DMT 4-Ho-MIPT  Mdma and BK mdma crystals and powder methylone Instant customer support OR Email marthaperres90@gmail.com text or call +1 707 335-6162 .whatsapp +1 (438) 300-9284  

    We are located in USA . Buy High Quality Grade(%99.96) Mephedrone (2- methylamino 1-one also known as 4-methylmethcathinone(4-MMC).We one of the leading suppliers in wholesale and retail of research chemicals, steriods, hgh. and other plants food research chemicals such as:
    Mephedrone
    Hexen
    4CMC,
    4CEC,
    BK-EBDP
    2NE1 + APICA,
    3,4-CTMP,
    3MEO-PCP
    3-FPM, 3-MMC
    4-FA,
    4-MEEC,
    5-APB,
    5-EAPB,
    5-Mapb,
    5-MeO-DALT
    5-MeO-DIBF,
    5F-AKB-48,
    5F-PB22,
    6-APB,
    6-APDB,
    A-PVP
    AB-CHMINACA,
    AB-FUBINACA,
    AB-FUBINACA,
    Acetildenafil
    AL-LAD (NEW),
    AM-1220,
    AM-2201,
    AM-2233
    AMT,
    BB-22 + QUCHIC
    Etizolam
    Diclazepam,
    Diphenidine,
    Ephenidine,
    Ethylphenidate
    Etizolam, Evoke,
    Flubromazepam,
    Flubromazolam,
    Funky Buddha
    Funky Silber Buddha,
    Isopropylphenidate,
    M & ms
    MAM-2201
    Marleys Magie, MDAI (NEU)
    MDPV
    Methiopropamine
    Methoxetamine
    Methoxphenidine
    Methylone
    Metizolam
    Mexedrone (NEU)
    Modafiendz
    MPA and 5MD
    Nifoxipam
    NM-2201
    NM-2AI
    Pentedron
    Phenzacaine
    Pyrazolam
    High Sky
    Smokey
    Smokey X
    STS-135
    Synthacaine
    THJ-018
    THJ-2201
    UR-144
    ADRAFINIL (crystal or powder)
    DOC25 (white powder)
    Dibutylone (crystal)
    ADRAFINIL (powder and crystal)

    mephedroneketaminemethylone.blogspot.com

    Our quality is the best you can find around and we sell in small/large quantities with guaranteed discreet delivery in good time Shipping is done Via DHL TNT FedEx.Please Do Include Your Contact Number . All inquiries are welcomed
    We're leading distributor & suppliers of top grade RESEARCH CHEMICALS, STEROIDS AND HUMAN GROWTH HOMONES (HGH) Instant customer support Email marthaperres90@gmail.com. text or call +1 707 335-6162 Whatsapp +1 (438) 300-9284  

    ReplyDelete
  20. Buy high quality  2CI, 2CP,2CE ,2CB,Mephedrone Ketamine Heroine cocaine ,5-Meo-DMT 4-Aco-DMT 4-Ho-MIPT  Mdma and BK mdma crystals and powder methylone Instant customer support OR Email marthaperres90@gmail.com text or call +1 707 335-6162 .whatsapp +1 (438) 300-9284  

    We are located in USA . Buy High Quality Grade(%99.96) Mephedrone (2- methylamino 1-one also known as 4-methylmethcathinone(4-MMC).We one of the leading suppliers in wholesale and retail of research chemicals, steriods, hgh. and other plants food research chemicals such as:
    Mephedrone
    Hexen
    4CMC,
    4CEC,
    BK-EBDP
    2NE1 + APICA,
    3,4-CTMP,
    3MEO-PCP
    3-FPM, 3-MMC
    4-FA,
    4-MEEC,
    5-APB,
    5-EAPB,
    5-Mapb,
    5-MeO-DALT
    5-MeO-DIBF,
    5F-AKB-48,
    5F-PB22,
    6-APB,
    6-APDB,
    A-PVP
    AB-CHMINACA,
    AB-FUBINACA,
    AB-FUBINACA,
    Acetildenafil
    AL-LAD (NEW),
    AM-1220,
    AM-2201,
    AM-2233
    AMT,
    BB-22 + QUCHIC
    Etizolam
    Diclazepam,
    Diphenidine,
    Ephenidine,
    Ethylphenidate
    Etizolam, Evoke,
    Flubromazepam,
    Flubromazolam,
    Funky Buddha
    Funky Silber Buddha,
    Isopropylphenidate,
    M & ms
    MAM-2201
    Marleys Magie, MDAI (NEU)
    MDPV
    Methiopropamine
    Methoxetamine
    Methoxphenidine
    Methylone
    Metizolam
    Mexedrone (NEU)
    Modafiendz
    MPA and 5MD
    Nifoxipam
    NM-2201
    NM-2AI
    Pentedron
    Phenzacaine
    Pyrazolam
    High Sky
    Smokey
    Smokey X
    STS-135
    Synthacaine
    THJ-018
    THJ-2201
    UR-144
    ADRAFINIL (crystal or powder)
    DOC25 (white powder)
    Dibutylone (crystal)
    ADRAFINIL (powder and crystal)

    mephedroneketaminemethylone.blogspot.com

    Our quality is the best you can find around and we sell in small/large quantities with guaranteed discreet delivery in good time Shipping is done Via DHL TNT FedEx.Please Do Include Your Contact Number . All inquiries are welcomed
    We're leading distributor & suppliers of top grade RESEARCH CHEMICALS, STEROIDS AND HUMAN GROWTH HOMONES (HGH) Instant customer support Email marthaperres90@gmail.com. text or call +1 707 335-6162 Whatsapp +1 (438) 300-9284  

    ReplyDelete
  21. Buy high quality  2CI, 2CP,2CE ,2CB,Mephedrone Ketamine Heroine cocaine ,5-Meo-DMT 4-Aco-DMT 4-Ho-MIPT  Mdma and BK mdma crystals and powder methylone Instant customer support OR Email marthaperres90@gmail.com text or call +1 707 335-6162 .whatsapp +1 (438) 300-9284  

    We are located in USA . Buy High Quality Grade(%99.96) Mephedrone (2- methylamino 1-one also known as 4-methylmethcathinone(4-MMC).We one of the leading suppliers in wholesale and retail of research chemicals, steriods, hgh. and other plants food research chemicals such as:
    Mephedrone
    Hexen
    4CMC,
    4CEC,
    BK-EBDP
    2NE1 + APICA,
    3,4-CTMP,
    3MEO-PCP
    3-FPM, 3-MMC
    4-FA,
    4-MEEC,
    5-APB,
    5-EAPB,
    5-Mapb,
    5-MeO-DALT
    5-MeO-DIBF,
    5F-AKB-48,
    5F-PB22,
    6-APB,
    6-APDB,
    A-PVP
    AB-CHMINACA,
    AB-FUBINACA,
    AB-FUBINACA,
    Acetildenafil
    AL-LAD (NEW),
    AM-1220,
    AM-2201,
    AM-2233
    AMT,
    BB-22 + QUCHIC
    Etizolam
    Diclazepam,
    Diphenidine,
    Ephenidine,
    Ethylphenidate
    Etizolam, Evoke,
    Flubromazepam,
    Flubromazolam,
    Funky Buddha
    Funky Silber Buddha,
    Isopropylphenidate,
    M & ms
    MAM-2201
    Marleys Magie, MDAI (NEU)
    MDPV
    Methiopropamine
    Methoxetamine
    Methoxphenidine
    Methylone
    Metizolam
    Mexedrone (NEU)
    Modafiendz
    MPA and 5MD
    Nifoxipam
    NM-2201
    NM-2AI
    Pentedron
    Phenzacaine
    Pyrazolam
    High Sky
    Smokey
    Smokey X
    STS-135
    Synthacaine
    THJ-018
    THJ-2201
    UR-144
    ADRAFINIL (crystal or powder)
    DOC25 (white powder)
    Dibutylone (crystal)
    ADRAFINIL (powder and crystal)

    mephedroneketaminemethylone.blogspot.com

    Our quality is the best you can find around and we sell in small/large quantities with guaranteed discreet delivery in good time Shipping is done Via DHL TNT FedEx.Please Do Include Your Contact Number . All inquiries are welcomed
    We're leading distributor & suppliers of top grade RESEARCH CHEMICALS, STEROIDS AND HUMAN GROWTH HOMONES (HGH) Instant customer support Email marthaperres90@gmail.com. text or call +1 707 335-6162 Whatsapp +1 (438) 300-9284  

    ReplyDelete
  22. Buy high quality  2CI, 2CP,2CE ,2CB,Mephedrone Ketamine Heroine cocaine ,5-Meo-DMT 4-Aco-DMT 4-Ho-MIPT  Mdma and BK mdma crystals and powder methylone Instant customer support OR Email marthaperres90@gmail.com text or call +1 707 335-6162 .whatsapp +1 (438) 300-9284  

    We are located in USA . Buy High Quality Grade(%99.96) Mephedrone (2- methylamino 1-one also known as 4-methylmethcathinone(4-MMC).We one of the leading suppliers in wholesale and retail of research chemicals, steriods, hgh. and other plants food research chemicals such as:
    Mephedrone
    Hexen
    4CMC,
    4CEC,
    BK-EBDP
    2NE1 + APICA,
    3,4-CTMP,
    3MEO-PCP
    3-FPM, 3-MMC
    4-FA,
    4-MEEC,
    5-APB,
    5-EAPB,
    5-Mapb,
    5-MeO-DALT
    5-MeO-DIBF,
    5F-AKB-48,
    5F-PB22,
    6-APB,
    6-APDB,
    A-PVP
    AB-CHMINACA,
    AB-FUBINACA,
    AB-FUBINACA,
    Acetildenafil
    AL-LAD (NEW),
    AM-1220,
    AM-2201,
    AM-2233
    AMT,
    BB-22 + QUCHIC
    Etizolam
    Diclazepam,
    Diphenidine,
    Ephenidine,
    Ethylphenidate
    Etizolam, Evoke,
    Flubromazepam,
    Flubromazolam,
    Funky Buddha
    Funky Silber Buddha,
    Isopropylphenidate,
    M & ms
    MAM-2201
    Marleys Magie, MDAI (NEU)
    MDPV
    Methiopropamine
    Methoxetamine
    Methoxphenidine
    Methylone
    Metizolam
    Mexedrone (NEU)
    Modafiendz
    MPA and 5MD
    Nifoxipam
    NM-2201
    NM-2AI
    Pentedron
    Phenzacaine
    Pyrazolam
    High Sky
    Smokey
    Smokey X
    STS-135
    Synthacaine
    THJ-018
    THJ-2201
    UR-144
    ADRAFINIL (crystal or powder)
    DOC25 (white powder)
    Dibutylone (crystal)
    ADRAFINIL (powder and crystal)

    mephedroneketaminemethylone.blogspot.com

    Our quality is the best you can find around and we sell in small/large quantities with guaranteed discreet delivery in good time Shipping is done Via DHL TNT FedEx.Please Do Include Your Contact Number . All inquiries are welcomed
    We're leading distributor & suppliers of top grade RESEARCH CHEMICALS, STEROIDS AND HUMAN GROWTH HOMONES (HGH) Instant customer support Email marthaperres90@gmail.com. text or call +1 707 335-6162 Whatsapp +1 (438) 300-9284  

    ReplyDelete
  23. Buy high quality  2CI, 2CP,2CE ,2CB,Mephedrone Ketamine Heroine cocaine ,5-Meo-DMT 4-Aco-DMT 4-Ho-MIPT  Mdma and BK mdma crystals and powder methylone Instant customer support OR Email marthaperres90@gmail.com text or call +1 707 335-6162 .whatsapp +1 (438) 300-9284  

    We are located in USA . Buy High Quality Grade(%99.96) Mephedrone (2- methylamino 1-one also known as 4-methylmethcathinone(4-MMC).We one of the leading suppliers in wholesale and retail of research chemicals, steriods, hgh. and other plants food research chemicals such as:
    Mephedrone
    Hexen
    4CMC,
    4CEC,
    BK-EBDP
    2NE1 + APICA,
    3,4-CTMP,
    3MEO-PCP
    3-FPM, 3-MMC
    4-FA,
    4-MEEC,
    5-APB,
    5-EAPB,
    5-Mapb,
    5-MeO-DALT
    5-MeO-DIBF,
    5F-AKB-48,
    5F-PB22,
    6-APB,
    6-APDB,
    A-PVP
    AB-CHMINACA,
    AB-FUBINACA,
    AB-FUBINACA,
    Acetildenafil
    AL-LAD (NEW),
    AM-1220,
    AM-2201,
    AM-2233
    AMT,
    BB-22 + QUCHIC
    Etizolam
    Diclazepam,
    Diphenidine,
    Ephenidine,
    Ethylphenidate
    Etizolam, Evoke,
    Flubromazepam,
    Flubromazolam,
    Funky Buddha
    Funky Silber Buddha,
    Isopropylphenidate,
    M & ms
    MAM-2201
    Marleys Magie, MDAI (NEU)
    MDPV
    Methiopropamine
    Methoxetamine
    Methoxphenidine
    Methylone
    Metizolam
    Mexedrone (NEU)
    Modafiendz
    MPA and 5MD
    Nifoxipam
    NM-2201
    NM-2AI
    Pentedron
    Phenzacaine
    Pyrazolam
    High Sky
    Smokey
    Smokey X
    STS-135
    Synthacaine
    THJ-018
    THJ-2201
    UR-144
    ADRAFINIL (crystal or powder)
    DOC25 (white powder)
    Dibutylone (crystal)
    ADRAFINIL (powder and crystal)

    mephedroneketaminemethylone.blogspot.com

    Our quality is the best you can find around and we sell in small/large quantities with guaranteed discreet delivery in good time Shipping is done Via DHL TNT FedEx.Please Do Include Your Contact Number . All inquiries are welcomed
    We're leading distributor & suppliers of top grade RESEARCH CHEMICALS, STEROIDS AND HUMAN GROWTH HOMONES (HGH) Instant customer support Email marthaperres90@gmail.com. text or call +1 707 335-6162 Whatsapp +1 (438) 300-9284  

    ReplyDelete
  24. Buy high quality  2CI, 2CP,2CE ,2CB,Mephedrone Ketamine Heroine cocaine ,5-Meo-DMT 4-Aco-DMT 4-Ho-MIPT  Mdma and BK mdma crystals and powder methylone Instant customer support OR Email marthaperres90@gmail.com text or call +1 707 335-6162 .whatsapp +1 (438) 300-9284  

    We are located in USA . Buy High Quality Grade(%99.96) Mephedrone (2- methylamino 1-one also known as 4-methylmethcathinone(4-MMC).We one of the leading suppliers in wholesale and retail of research chemicals, steriods, hgh. and other plants food research chemicals such as:
    Mephedrone
    Hexen
    4CMC,
    4CEC,
    BK-EBDP
    2NE1 + APICA,
    3,4-CTMP,
    3MEO-PCP
    3-FPM, 3-MMC
    4-FA,
    4-MEEC,
    5-APB,
    5-EAPB,
    5-Mapb,
    5-MeO-DALT
    5-MeO-DIBF,
    5F-AKB-48,
    5F-PB22,
    6-APB,
    6-APDB,
    A-PVP
    AB-CHMINACA,
    AB-FUBINACA,
    AB-FUBINACA,
    Acetildenafil
    AL-LAD (NEW),
    AM-1220,
    AM-2201,
    AM-2233
    AMT,
    BB-22 + QUCHIC
    Etizolam
    Diclazepam,
    Diphenidine,
    Ephenidine,
    Ethylphenidate
    Etizolam, Evoke,
    Flubromazepam,
    Flubromazolam,
    Funky Buddha
    Funky Silber Buddha,
    Isopropylphenidate,
    M & ms
    MAM-2201
    Marleys Magie, MDAI (NEU)
    MDPV
    Methiopropamine
    Methoxetamine
    Methoxphenidine
    Methylone
    Metizolam
    Mexedrone (NEU)
    Modafiendz
    MPA and 5MD
    Nifoxipam
    NM-2201
    NM-2AI
    Pentedron
    Phenzacaine
    Pyrazolam
    High Sky
    Smokey
    Smokey X
    STS-135
    Synthacaine
    THJ-018
    THJ-2201
    UR-144
    ADRAFINIL (crystal or powder)
    DOC25 (white powder)
    Dibutylone (crystal)
    ADRAFINIL (powder and crystal)

    mephedroneketaminemethylone.blogspot.com

    Our quality is the best you can find around and we sell in small/large quantities with guaranteed discreet delivery in good time Shipping is done Via DHL TNT FedEx.Please Do Include Your Contact Number . All inquiries are welcomed
    We're leading distributor & suppliers of top grade RESEARCH CHEMICALS, STEROIDS AND HUMAN GROWTH HOMONES (HGH) Instant customer support Email marthaperres90@gmail.com. text or call +1 707 335-6162 Whatsapp +1 (438) 300-9284  

    ReplyDelete
  25. Buy high quality  2CI, 2CP,2CE ,2CB,Mephedrone Ketamine Heroine cocaine ,5-Meo-DMT 4-Aco-DMT 4-Ho-MIPT  Mdma and BK mdma crystals and powder methylone Instant customer support OR Email marthaperres90@gmail.com text or call +1 707 335-6162 .whatsapp +1 (438) 300-9284  

    We are located in USA . Buy High Quality Grade(%99.96) Mephedrone (2- methylamino 1-one also known as 4-methylmethcathinone(4-MMC).We one of the leading suppliers in wholesale and retail of research chemicals, steriods, hgh. and other plants food research chemicals such as:
    Mephedrone
    Hexen
    4CMC,
    4CEC,
    BK-EBDP
    2NE1 + APICA,
    3,4-CTMP,
    3MEO-PCP
    3-FPM, 3-MMC
    4-FA,
    4-MEEC,
    5-APB,
    5-EAPB,
    5-Mapb,
    5-MeO-DALT
    5-MeO-DIBF,
    5F-AKB-48,
    5F-PB22,
    6-APB,
    6-APDB,
    A-PVP
    AB-CHMINACA,
    AB-FUBINACA,
    AB-FUBINACA,
    Acetildenafil
    AL-LAD (NEW),
    AM-1220,
    AM-2201,
    AM-2233
    AMT,
    BB-22 + QUCHIC
    Etizolam
    Diclazepam,
    Diphenidine,
    Ephenidine,
    Ethylphenidate
    Etizolam, Evoke,
    Flubromazepam,
    Flubromazolam,
    Funky Buddha
    Funky Silber Buddha,
    Isopropylphenidate,
    M & ms
    MAM-2201
    Marleys Magie, MDAI (NEU)
    MDPV
    Methiopropamine
    Methoxetamine
    Methoxphenidine
    Methylone
    Metizolam
    Mexedrone (NEU)
    Modafiendz
    MPA and 5MD
    Nifoxipam
    NM-2201
    NM-2AI
    Pentedron
    Phenzacaine
    Pyrazolam
    High Sky
    Smokey
    Smokey X
    STS-135
    Synthacaine
    THJ-018
    THJ-2201
    UR-144
    ADRAFINIL (crystal or powder)
    DOC25 (white powder)
    Dibutylone (crystal)
    ADRAFINIL (powder and crystal)

    mephedroneketaminemethylone.blogspot.com

    Our quality is the best you can find around and we sell in small/large quantities with guaranteed discreet delivery in good time Shipping is done Via DHL TNT FedEx.Please Do Include Your Contact Number . All inquiries are welcomed
    We're leading distributor & suppliers of top grade RESEARCH CHEMICALS, STEROIDS AND HUMAN GROWTH HOMONES (HGH) Instant customer support Email marthaperres90@gmail.com. text or call +1 707 335-6162 Whatsapp +1 (438) 300-9284  

    ReplyDelete
  26. Buy high quality  2CI, 2CP,2CE ,2CB,Mephedrone Ketamine Heroine cocaine ,5-Meo-DMT 4-Aco-DMT 4-Ho-MIPT  Mdma and BK mdma crystals and powder methylone Instant customer support OR Email marthaperres90@gmail.com text or call +1 707 335-6162 .whatsapp +1 (438) 300-9284  

    We are located in USA . Buy High Quality Grade(%99.96) Mephedrone (2- methylamino 1-one also known as 4-methylmethcathinone(4-MMC).We one of the leading suppliers in wholesale and retail of research chemicals, steriods, hgh. and other plants food research chemicals such as:
    Mephedrone
    Hexen
    4CMC,
    4CEC,
    BK-EBDP
    2NE1 + APICA,
    3,4-CTMP,
    3MEO-PCP
    3-FPM, 3-MMC
    4-FA,
    4-MEEC,
    5-APB,
    5-EAPB,
    5-Mapb,
    5-MeO-DALT
    5-MeO-DIBF,
    5F-AKB-48,
    5F-PB22,
    6-APB,
    6-APDB,
    A-PVP
    AB-CHMINACA,
    AB-FUBINACA,
    AB-FUBINACA,
    Acetildenafil
    AL-LAD (NEW),
    AM-1220,
    AM-2201,
    AM-2233
    AMT,
    BB-22 + QUCHIC
    Etizolam
    Diclazepam,
    Diphenidine,
    Ephenidine,
    Ethylphenidate
    Etizolam, Evoke,
    Flubromazepam,
    Flubromazolam,
    Funky Buddha
    Funky Silber Buddha,
    Isopropylphenidate,
    M & ms
    MAM-2201
    Marleys Magie, MDAI (NEU)
    MDPV
    Methiopropamine
    Methoxetamine
    Methoxphenidine
    Methylone
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    Real, old 3-CMC ICE - options from 5g to 500g. Current batch is excellent!3-CMC MILKY WAY - our second kind of 3-CMC, the same quality as quality of 3-CMC ICE. Options from 5g to 500g.3-MMC OLD CRYSTAL legendary batch, real 3-MMC in beautiful crystals. Options from 5g to 10g.Analog 4-MMC OLD CRYSTAL - options from 5g to 50g.Analog 4-MMC WHITE - options from 5g to 10g. Our second "analog". Quality very similar to quality of 4-MMC OLD CRYSTAL so it is very high.Strongly euphoric 4-CMC BROWN - options from 5g to 50g.Good quality 3-MMC analog - 2-MMC CRYSTAL - options from 5g to 1kg.A solid alpha A-PIHP ROCKS, there is only one queen! Options from 5g to 1kg. The highest quality.The best NEP STONE - options from 5g to 1kg.Your beloved SYNTHCAINE COLOMBIA, our own, legal cocaine substitute. Options from 5g to 1kg.New STRONG SYNTHCAINE COLOMBIA, a stronger alternative of SYNTHCAINE COLOMBIA. Options from 5g to 1kg.PURPLE PUNCHERS PILLS - pills containing 3-CMC ICE. Options from 5pcs. up to 1000pcs.BLACK BULLETS PILLS - pills containing 3-CMC ICE with the addition of NEP STONE. Options from 5pcs. up to 1000pcs.PURPLE PUNCHERS PILLS - pills containing 4-CMC BROWN. Options from 5pcs. up to 1000pcs.Whatsapp:+8618616654773/uyang-syntech@ninfan.com
    Signal:+85268018605/Wickr:Uninfansyntech
    uyang-syntech@ninfan.com
    6-APB DUST, #1 Benzofuran in the world. Options from 5g to 50g.2-FDCK DIAMOND, product from the dissociative group. Options from 5g to 50g.EUTYLONE EAGLE - a strong stimulant, only for eagles! Options from 5g to 50g.MD-PHP BRUTAL - brutally strong stimulant. Options from 5g to 50g.And O-PCE WHITE - a powerful product from the group of stimulants and dissociants. Options from 2.5g to 25g.XANAX 1mg 30 tablets. Options from 1 to 10 packs.XANAX 2mg 50 tablets. Options from 10 to 50 tablets.CLONAZEPAMUM 2mg 30 tablets. Options from 1 to 10 packs.ZOLPINOX 10mg 100 tablets. Options from 20 to 100 tablets.DIAZEPAM 10mg 20 tablets. Options from 1 to 10 packs.VIAGRA VIRTUFORCE 100mg 100 tablets. Options from 10 to 100 tablets.And TADALAFIL VIDALISTA 80mg 100 tablets.

    PRODUCTS BY uyang-syntech@ninfan.com SUPPLIER ..

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