tag:blogger.com,1999:blog-6010505890506526002.post357540065127193735..comments2024-03-18T22:53:05.428-04:00Comments on Just Like Cooking: Turning Wishes into HorsesSee Arr Ohhttp://www.blogger.com/profile/09464185815368499346noreply@blogger.comBlogger6125tag:blogger.com,1999:blog-6010505890506526002.post-83757347101681612362013-01-08T12:48:18.109-05:002013-01-08T12:48:18.109-05:00http://chem.chem.rochester.edu/nvdcgi/mojo.cgi
her...http://chem.chem.rochester.edu/nvdcgi/mojo.cgi<br />here is the page with the hard to reproduce experimentsAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-6010505890506526002.post-76451780297961934362013-01-07T12:06:56.213-05:002013-01-07T12:06:56.213-05:00Evans aldol needs good air-free technique/pure dry...Evans aldol needs good air-free technique/pure dry solvents and the Lewis acid reagent Bu2BOTf craps up if stored improperly. So it could have been one desperate grad student in a bio- lab trying to reproduce a "surefire" transformation without anyone to tell him that one has to check for presence of MeOH in DCM from a Fisher can (CaH2 or Al2O3 solvent purification column wont remove 0.5% of MeOH in DCM). And so onmilkshakehttp://orgprepdaily.wodpress.comnoreply@blogger.comtag:blogger.com,1999:blog-6010505890506526002.post-32766568386035402332013-01-06T20:37:58.217-05:002013-01-06T20:37:58.217-05:00For a while, Alison Frontier's Not Voodoo had ...For a while, Alison Frontier's Not Voodoo had a section for papers that were irreproducible -- naturally, the Evans aldol ended up on there, which I found odd (and so did commenters.) <br /><br />I don't really know what happened to it -- I can't find it when I went looking. <br /><br />"Blog Syn" sounds like a decent idea; one could imagine that a Blog Syn contribution could be a required part of a candidacy exam.Chemjobberhttps://www.blogger.com/profile/15932113680515602275noreply@blogger.comtag:blogger.com,1999:blog-6010505890506526002.post-86622801993329656512013-01-06T15:11:43.129-05:002013-01-06T15:11:43.129-05:00I think this sounds like a good idea. At the very ...I think this sounds like a good idea. At the very least, a curated, searchable collection of online discussions related to literature (i.e. pop in the DOI and see what people have said, tried, etc) would be very valuable--it would be easy for people to search before ordering reagents to try a procedure.<br /><br />A concern would be, of course, trying procedures: it would be important, I think, to get some PIs to jump on board so as to not provoke anger when they find out their grad student has been chewing up reagents and time for a non-research pursuit. Of course, some people have autonomy to try things, some don't. But there are PIs who have their students participate in Org Syn, so I think it's feasible.vinylogoushttps://www.blogger.com/profile/04278027233887601040noreply@blogger.comtag:blogger.com,1999:blog-6010505890506526002.post-34936600815079123082013-01-06T14:04:10.944-05:002013-01-06T14:04:10.944-05:00A tough (but important) lesson to learn, as early ...A tough (but important) lesson to learn, as early as possible!See Arr Ohhttps://www.blogger.com/profile/09464185815368499346noreply@blogger.comtag:blogger.com,1999:blog-6010505890506526002.post-91444968254142660042013-01-06T13:55:39.433-05:002013-01-06T13:55:39.433-05:00This might also be great to teach 1st years or rot...This might also be great to teach 1st years or rotation students a lesson about believing preps, and to give them some lab experience before ruining otherwise precious material.Anonymousnoreply@blogger.com